The Physiological Action of Some Pyrimidine Compounds of the Barbituric Acid Series

Wiihler and Frerichsl fed 5 to 6 grams of this to men but could not recover any in the urine; nor was alloxan found. The urine was rich in urea, and a breaking down of alloxantine to urea and other products was believed to be probable. No mention is made of any toxic effects, although if any had been experienced they would undoubtedly have been described because the subjects were human beings. Koehne2 fed alloxan and alloxantine in S-gram doses to dogs. Each caused a mild diarrhea without other symptoms. No alloxan or alloxantine was excreted in the urine; but small amounts of oxalic and parabanic acids were found. Working independently of Koehne with t&e same compounds Lusinia obtained results different in some respects at least. In his experi-